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Tuesday, June 18, 2013

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Scientific Papers


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PARTICIPANTS
Presenter
Rizwan	Aslam	MBChB
Abstract Co-Author
Judy	Yee	MD
Alexander	Keedy	MD
Timothy	Joseph	MD
Alex	Chau	BS

SUBSPECIALTY CONTENT
	Musculoskeletal Radiology

	CODE: SSG13-09
	SESSION: Musculoskeletal (Osteoporosis)
	Assessment of Bone Mineral Density on CT Colonography


	DATE:	Tuesday, December 02 2008
	START TIME:	11:50 AM
	END TIME:	12:00 PM
	LOCATION:	S505AB

	DISCLOSURES
	R.A.	- Nothing to disclose.
	J.Y.	- Research grant, General Electric Company
	A.K.	- Nothing to disclose.
	T.J.	- Nothing to disclose.
	A.C.	- Nothing to disclose.

	PURPOSE
	This is a retrospective study evaluating the bone mineral density (BMD) measurements derived from CT Colonography (CTC) datasets compared with bone mineral density measurements derived from DEXA in the same patients.
	METHOD AND MATERIALS
	Two readers independently calculated BMD and T scores from 35 CTC datasets. All CT scans were performed on a 16 slice MDCT scanner (GE Healthcare) and DEXA measurements were obtained on a Hologic Discovery series A machine. CT bone density analysis was performed on a workstation using a specific bone mineral analysis package (Philips). The bone density measurements were obtained using 3 vertebral bodies from T12 to the L1 level. Density measurements were also obtained from fat and muscle structures to provide an internal reference from which the BMD T score and Z score are calculated. In total we assessed 35 patients of which 30 were males and 5 females, the mean age was 66 (age range 54-79).
	RESULTS
	35 patients were evaluated who underwent CTC and also had DEXA BMD measurements. There were 30 males and 5 females, with a mean age of 66 years (age range 54-79). There was a correlation of 0.41 (p<0.0001) and 0.39 (p<0.0001) for the CT and Dexa BMD reading per vertebral body level, and 0.5 (p<0.0001) and 0.51 (p<0.0001) for the CT and Dexa T score per vertebral body for reader 1 and 2 respectively. For the CT and Dexa BMD averaged for all vertebra there was a correlation of 0.66 (p<0.0001) and 0.61 (p<0.0001) for reader 1 and 2 respectively. The CT and Dexa T score average was 0.6 (p<0.0001) and 0.59 (p<0.0001) for reader 1 and 2 respectively. The mean Dexa and CT, for BMD and T values were 1.009, 90.9 and -0.78, -2.14 respectively. Kappa was 0.69 per vertebral level and 0.75 overall.
	CONCLUSION
	There was excellent agreement between the retrospectively derived BMD and T scores from the CTC data set and the patients BMD measurements and T scores generated from DEXA to assess patient’s osteoporosis status. The results were also reproducible with good interobserver agreement

	CLINICAL RELEVANCE/APPLICATION
	In this study we used patients who underwent CTC as they would also be at risk for osteoporosis. We were able to identify patients with osteoporosis on CTC, as well as screen for colorectal cancer.

	QUESTIONS ABOUT THIS EVENT EMAIL:
	rizwan.aslam@radiology.ucsf.edu